Ras proteins function as critical relay switches that regulate diverse signaling pathways between cell surface receptors and the nucleus. Over the past 2‐3 years researchers have identified many components of these pathways that mediate Ras activation and effector function. Among these proteins are several guanine nucleotide exchange factors (GEFs), which are responsible for directly interacting with and activating Ras in response to extracellular stimuli. Analogous GEFs regulate Ras‐related proteins that serve other diverse cellular functions. In particular, a growing family of (...) proteins (Dbl homology proteins) has recently been identified, which may function as GEFs for the Rho family of Ras‐related proteins. This review summarizes our current knowledge of the structure, biochemistry and biology of Ras and Rho family GEFs. Additionally, we describe mechanisms of GEF activation of Ras in signal transduction and address the potential that deregulated GEFs might contribute to malignant transformation through chronic Ras protein activation. (shrink)

En el presente artículo se defiende la tesis de que existe un concepto globalizable de justicia a pesar de las diferencias culturales. Este concepto se basa en la igualdad con miras al establecimiento de un orden jurídico global democrático que garantice la administración de la justicia al interior de y entre los Estados. El artículo ofrece un marco conceptual de la posibilidad de dicho orden jurídico global democrático y de los retos y tareas a los cuales se enfrenta en su (...) pretensión de suministrar criterios sociales y de protección del medio ambiente para la puesta en marcha de una política de desarrollo global. (shrink)

In the study of Buddhism it is commonly accepted that a monk or nun who commits a pārājika offence is permanently and irrevocably expelled from the Buddhist monastic order. This view is based primarily on readings of the Pāli Vinaya. With the exception of the Pāli Vinaya, however, all other extant Buddhist monastic law codes (Dharmaguptaka, Mahāsāṅghika, Mahīśāsaka, Sarvāstivāda and Mūlasarvāstivāda) contain detailed provisions for monks and nuns who commit pārājikas but nevertheless wish to remain within the saṅgha. These monastics (...) are not expelled. Rather, they are granted a special status known as the śikṣādattaka. In this paper I explore the rules. concerning pārājika penance and the śikṣādattaka with specific regard to monastic celibacy. Given that five out of six extant law codes recognise this remarkable accommodation to the rule of celibacy, I argue that we must look to Vinayas other than the Pāli Vinaya if we are to arrive at a nuanced and representative view of Indian Buddhist monasticism. Grant me chastity and continence, but not yet.Augustine of Hippo (354–430 C.E.). (shrink)

Is it possible to be a citizen of the world? Cosmopolitan thought has been at the center of recent debates surrounding human rights, legal obligations, international relations and political responsibility. Most of these debates trace their origins to the Enlightenment of the Eighteenth Century or to the teaching of Greek and Roman philosophers. This collection of essays uncovers a wide array of medieval writings on cosmopolitan ethics and politics, writings generally ignored or glossed over in contemporary discourse. Medieval literary fictions (...) and travel accounts provide us with rich contextualizations of the complexities and contradictions of cosmopolitan thought. (shrink)

It has been claimed that Indian Buddhism, as opposed to East Asian Chan/Zen traditions, was somehow against humour. In this paper I contend that humour is discernible in canonical Indian Buddhist texts, particularly in Indian Buddhist monastic law codes (Vinaya). I will attempt to establish that what we find in these texts sometimes is not only humourous but that it is intentionally so. I approach this topic by comparing different versions of the same narratives preserved in Indian Buddhist monastic law (...) codes. (shrink)

In the business ethics literature, a commons paradigm orients theorizing toward how civil society can promote collaboration and collectively govern shared resources, and implicates the common good—the ethics of providing social conditions that enable individuals and collectives to thrive. In the context of representative democracies, the shared resources of a nation can be considered commons, yet these resources are governed in a top-down, bureaucratic manner wherein public participation is often limited to voting for political leaders. Such governance, however, can be (...) motivated by values of solidarity and stewardship, and a bottom-up approach to participation, in ways that are consistent with a social commons ethos. We employ an inductive methodology focused on successes and possibilities, using data from interviews with 93 policy-makers and national-level government leaders in 5 democratic countries, and observational and archival data. We reveal how governments can operationalize a social commons ethos in decision-making. This approach to governance involves stakeholder engagement that is Broad, Deep, and Continual. In this model, leaders engage a wide breadth of stakeholders, engage them deeply and meaningfully throughout the decision-making process, and sustain this engagement in a continual manner. Implications for governance of non-governmental bureaucracies are discussed, including the normative and strategic benefits of engaging stakeholders in this manner. (shrink)

Online science and engineering ethics (SEE) education can support appropriate goals for SEE and the highly interactive pedagogy that attains those goals. Recent work in moral psychology suggests pedagogical goals for SEE education that are surprisingly similar to goals enunciated by several panels in SEE. Classroom-based interactive study of SEE cases is a suitable method to achieve these goals. Well-designed cases, with appropriate goals and structure can be easily adapted to courses that have online components. It is less clear that (...) exclusively online methods can support the wide range of goals necessary to good moral pedagogy in SEE, though there seems no a priori reason to rule this out. Only careful, goal-based assessment of online case study SEE teaching can resolve this question. (shrink)

This paper argues that Mencius is a eudaimonist, and that his eudaimonism plays an architectonic role in his thought. Mencius maintains that the most satisfying life for a human being is the life of benevolence, rightness, wisdom, and ritual propriety, and that such a life fulfills essential desires and capacities of the human heart. He also repeatedly appeals both to these and to morally neutral desires in his efforts to persuade others to develop and exercise the virtues. Classical Greek eudaimonists (...) similarly regarded the life of virtue as both objectively good and subjectively desirable, and appealed to the desire for eudaimonia or happiness to motivate a commitment to the virtues. Mencius offers a carefully crafted, teleological account of human nature that appears designed in part to support his eudaimonism. In contrast with proposals by other scholars, I argue that Mencius’ notion of happiness, analogous to the Greek eudaimonia, is expressed by the construction jìn xìng 盡性, “fulfilling human nature” or the nearly equivalent jìn xīn 盡心, “fulfilling one’s heart.”. (shrink)

PurposeThe purpose of this paper is to present a four component model of ethical behavior (PRIMES) that integrates literature in moral psychology, computing ethics, and virtue ethics as informed by research on moral exemplars in computing. This is part 1 of a two‐part contribution.Design/methodology/approachThis psychologically based and philosophically informed model argues that moral action is: grounded in relatively stable PeRsonality characteristics (PR); guided by integration of morality into the self‐system; shaped by the context of the surrounding moral ecology; and facilitated (...) by morally relevant skills and knowledge (S).FindingsThe model seeks to explain the daily successful (and unsuccessful) performance of moral action by computing professionals and to provide groundwork for a pedagogy that emphasizes ethically effective performance.Practical implicationsThe model has significant implications for how ethical action might be taught to computer professionals and other design professionals. It also makes recommendations about what is needed to measure to construct a complete picture of sustained ethical action in a profession.Originality/valueMost accepted models of ethical behavior are unidimensional, emphasizing either principled reasoning or a simplistic model of integrity/character. This model brings together a variety of disparate literatures in the light of its emphasis on sustained moral action in the profession. It thereby provides researchers and educators with a picture of what is needed to construct a complete understanding of moral action in the profession. (shrink)

PurposeThe purpose of this paper is to present a four component model of ethical behavior that integrates literature in moral psychology, computing ethics, and virtue ethics as informed by research on moral exemplars in computing. This is part 2 of a two part contribution, part 1 having appeared in Vol. 6 No. 3.Design/methodology/approachThis psychologically based and philosophically informed model argues that moral action is grounded in relatively stable personality characteristics, guided by integration of morality into the self‐system, shaped by the (...) context of the surrounding moral ecology, and facilitated by morally relevant skills and knowledge.FindingsThe model seeks to explain the daily successful (and unsuccessful) performance of moral action by computing professionals and to provide groundwork for a pedagogy that emphasizes ethically effective performance.Practical implicationsThe model has significant implications for how ethical action to computer professionals and other design professionals might be taught. It also makes recommendations about what need to be measured to construct a complete picture of sustained ethical action in a profession.Originality/valueMost accepted models of ethical behavior are unidimensional, emphasizing either principled reasoning or a simplistic model of integrity/character. This model brings together a variety of disparate literatures in the light of its emphasis on sustained moral action in the profession. It thereby provides researchers and educators with a picture of what is needed to construct a complete understanding of moral action in the profession. (shrink)

In the Deese-Roediger/McDermott paradigm, distinctive encoding of list items typically reduces false recognition of critical lures relative to a read-only control. This reduction can be due to enhanced item-specific processing, reduced relational processing, and/or increased test-based monitoring. However, it is unclear whether distinctive encoding reduces false recognition in a selective or global manner. To examine this question, participants studied DRM lists using a distinctive item-specific anagram generation task and then completed a recognition test which included both DRM critical lures and (...) either strongly related lures or weakly related lures. Compared to a read-control group, the generate groups showed increased correct recognition and decreased false recognition of all lure types. We then estimated the separate contributions of encoding and retrieval processes using signal-detection indices. Generation improved correct recognition by both increasing encoding of memory information for list words and by increasing memory monitoring at test. Generation reduced false recognition by reducing the encoding of memory information and by increasing memory monitoring at test. The reduction in false recognition was equivalent for critical lures and related lures, indicating that generation globally reduces the encoding of related non-presented items at study, while globally increasing list-theme-based monitoring at test. (shrink)

(1997). Science and the public sphere: Comparative institutional development in Islam and the West. Social Epistemology: Vol. 11, No. 1, pp. 25-37. doi: 10.1080/02691729708578827.

Wand argues in "hume's account of obligation" that hume's view of obligation precludes 'our recognizing, After deliberate reflection, That... A certain action is right, And our failure to carry it out makes us morally responsible for it.' huff argues that wand's failure to distinguish the motives which originate the conventions of society from the motives which sustain such conventions leads to an inadequate account of hume's view of moral obligation and responsible action.

Mencius maintains that the most satisfying life for a human being is the life of benevolence, rightness, wisdom and ritual propriety. He also repeatedly appeals to happiness in his efforts to persuade others to develop and exercise the virtues. Mencius is therefore a eudaimonist. He offers a carefully crafted, teleological account of human nature that appears designed in part to support his eudaimonism. In contrast with proposals by other scholars, I argue that Mencius’ distinctive conception of happiness is best expressed (...) by the construction jin xing 盡性, “fulfilling human nature” or the nearly equivalent jin xin 盡心, “fulfilling one’s heart.” The fact that human nature includes the sprouts of the four chief virtues allows Mencius to resolve common concerns about happiness as a motive for virtue. In addition to supporting his eudaimonism, Mencius’ conception of human nature also conceptually unifies his vision for human flourishing, including its emotional, material, social, moral, and cosmic dimensions. (shrink)

Three questions animate Tuomo Tiisala's essay, “Overcoming ‘the Present Limits of the Necessary’: Foucault's Conception of a Critique”: What is the task of critique, as Foucault describes it? What is it about reason that necessitates such a task? And what is it that could motivate the critical attitude as a virtue?

Purpose This viewpoint aims to highlight the necessarily technical nature of ethics in software development, propose a label for ethical analysis that does not lead to ethical action and introduce a philosophical foundation for technical analysis that leads to ethical software development. Design/methodology/approach The methodological approach is one of technical analysis that is aware of social science and philosophical knowledge bases. Findings The findings establish a clear technical foundation that is crucial to ethical analysis that will actually inform software development. (...) Research limitations/implications The idea that beginning with technical expertise is the best way to begin ethical reflection on a technical implementation has been often suggested, but not really empircally tested. Research using cases or other qualitative approaches would need to be done to add credibility to the claim. Practical implications This approach suggests that collaboration between technically informed ethicists and ethically informed technical experts should begin with the exploration of the technical questions rather than with ethical speculation. Social implications A common approach to ethical education is to concentrate on ethical theory and its application in technical contexts. This approach suggests that this may lead to ethical bypassing by the student, the avoidance of the making technical decisions by extensive ethical reflection. Originality/value This paper introduces a new term, ethical bypassing, to the literature on the ethics of software development. (shrink)

For beings that have a beginning in time, free will seems impossible, because our choices seem to be a result of past events over which we had no control. Latter-day Saint theology offers what seems a simple solution: the idea that human beings have always existed in the form of spirits or “intelligences.” While this idea solves some key puzzles, contemplating an infinite past also brings the recognition that causal autonomy is not enough for freedom. A crucial feature of humanity (...) is the ability to move beyond past choices and versions of ourselves. Human freedom involves a dynamic process of identification, alienation, and re-identification through which we develop, improve, and mature as agents. Thinking about freedom over the long run, with attention to both the past and the future, casts the traditional debate over free will in a distinctive light, suggesting fresh possibilities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:In Memoriam:Benjamin Lee Wren (1931–2006)Peter A. HuffAlmost a year after Hurricanes Katrina and Rita devastated his beloved New Orleans, Benjamin Wren, longtime member of the history department at Loyola University–New Orleans, died on July 20, 2006. Wren joined the Loyola faculty in 1970 and taught popular courses in Chinese history, Japanese history, and world history. He is best remembered for his unprecedented courses in Zen and the unique campus (...) zendo where he taught them. His courses integrated meditation practice, philosophical reflection, historical investigation, and a bit of group therapy into what many students have described as life-changing experiences.Wren was the son of an American Marine and a Hong Kong native who met in Tientsin, China. Growing up in the American South during the Great Depression and World War II, he encountered firsthand the racism and xenophobia that defined the Bible Belt as a distinct cultural region in the first half of the twentieth century. He entered the Society of Jesus when he was seventeen years of age and earned degrees from Spring Hill College, Saint Louis University, and the University of Arizona. Nearly fifty years later, he left the Jesuits and married Patricia Wren.Wren's professional life did not follow the path of the conventional academic career. For several years he taught in Jesuit high schools. After discovering a book on the Japanese art of flower arranging in a Texas public library, he pursued graduate studies in Asian religion and history. Like many of his generation, he was influenced by Jean Dechanet's Christian Yoga and Dom Aelred Graham's Zen Catholicism. He studied Zen with Yamada Roshi in Kamakura and ikebana with Sofu Teshigahara of the Sogetsu School in Tokyo. He initiated his Zen courses at Loyola partially in response to student unrest in the wake of the Kent State massacre.Wren published very little and did not easily negotiate the tenure process. His Zen among the Magnolias (1999) represents more personal testimony than scholarly argument. He did, however, have the extraordinary ability to stretch his students' imaginations and aspirations beyond the formal limitations of higher education and professional expectations. I saw this dimension of his [End Page 137] work very clearly when he served as the keynote speaker for Centenary College's 2004 one-day conference on "The Dharma in Dixie," a program featuring leaders and practitioners from Louisiana's Hindu and Buddhist communities. Wren's animated talk, fusing a whirlwind tour of Chinese history with a riveting critique of contemporary American culture, was by all accounts the highlight of the event.In Zen among the Magnolias, Wren wrote, "The two symbols used to write the word Zen are the symbols for God and warfare. For us who come out of a Judaic/ Christian background, we have the tradition of Jacob fighting with God and emerging from the fight with a new name, Israel (He who has fought with God)" (p. 7). By the time he spoke at my institution, Wren was already engaged in his final battle with cancer. During the chaos of Hurricane Katrina, we lost track of each other. Then I heard of the memorial service to be held in his honor at an Episcopal church in a New Orleans suburb."Zen Ben" Wren's brand of personal passion and intellectual integrity is a rare commodity in today's corporate academy. "The best teachers," he said, "never lose their student IDs, and they also bring out the master in their respective students" (p. 16). Loyola's zendo once housed an unforgettable teacher. [End Page 138]Peter A. HuffCentenary College of LouisianaCopyright © 2007 The University of Hawai'i Press... (shrink)